1 in 8
MenDiagnosed with prostate cancer in their lifetime.
10–15 min
Enhanced Prostate Screening examNo contrast, no endorectal probe, zero radiation.
99%
5-year relative survivalWhen detected at an early, localized stage (American Cancer Society).
Enhanced Prostate Screening
Screening has long leaned on PSA, where a raised result more often means an enlarged or inflamed prostate than cancer — and the answer was a blind 12-core biopsy. EPS puts MRI first, evaluating the gland with the support of DeepHealth’s prostate AI before anyone reaches for a needle.
Offered in Arizona, California, Delaware, New York and Texas. Check availability near you.
What to expect
No PSA required
A PSA test is recommended but not required. Talk with your doctor about whether screening is right for you.
For men 45 and older
Who have not had a previous prostate biopsy or a prostate cancer diagnosis.
A 10–15 minute exam
Quick appointment turnaround, with online access to reports and images.
No IV contrast
Non-invasive, with no endorectal probe and zero radiation.
Minimal prep
A clear-liquid diet from eight hours before, and two Gas-X soft gels beforehand.
Built for claustrophobia
Your head stays outside the scanner for the whole exam.
Is EPS right for you?
- Men aged 45 and older seeking a baseline or routine prostate evaluation.
- Men with a family history of prostate cancer.
If your PSA is 10 or greater, a diagnostic prostate MRI is recommended instead — billed to insurance; please have a conversation with your provider. See Prostate MRI below.
The EPS clinical pathway
A fast, non-contrast MRI of the gland. No dye, no rectal probe, no radiation.
DeepHealth’s Prostate Suite segments the gland, measures its volume, calculates PSA density and flags candidate targets.
A contracted radiologist reviews the study and assigns a PI-RADS score.
Enhanced Prostate Screening is not yet covered by insurance. The exam is $275.
Men need to learn how to fight like women. Through advocacy and education women have become empowered to improve the way breast cancer is provided. Men are 20 years behind. Medicine’s ability to accurately screen, stage, and treat prostate cancer has never been better, and men can demand innovative care such as Enhanced Prostate Screening with AI and MRI technology.
Robert Princenthal, M.D. · Director of RadNet’s Prostate Program
Key advantages of EPS
No contrast, no endorectal probe
Uses fast, non-contrast MRI sequences. Comfortable and completely non-invasive.
DeepHealth Prostate Suite
Automatically estimates prostate gland volume, computes PSA density (serum PSA divided by prostate volume) and highlights suspicious regions.
Avoids unnecessary biopsies
Identifies men with low-risk or benign glands who may be able to avoid an invasive TRUS biopsy.
+27%
Finds more lesions
In DeepHealth’s reader study submitted for FDA clearance, radiologists using its prostate AI detected 27% more lesions than without it (data on file).
Prostate MRI
Screening is one use of the scan. Prostate MRI also stages disease that has already been found, guides a targeted biopsy, and follows men on active surveillance — and it is the reason a rising PSA no longer has to mean a needle.
When prostate MRI is used
- Detection For men with an elevated PSA, with or without a previous negative biopsy. Reading the MRI first gives better information before anyone proceeds to biopsy, and means fewer unnecessary ones. It also identifies infection, benign prostatic hyperplasia and congenital abnormalities.
- Staging After a positive biopsy, MRI measures tumor size and extent, and helps show whether the disease is confined to the gland or has spread beyond the capsule — information used to plan surgery or radiation.
- Surveillance & recurrence Men on active surveillance for low-risk disease are scanned regularly to watch for signs of higher-grade disease. For those treated with surgery or radiation whose PSA rises again, MRI helps establish whether the cancer has returned.
- The experience behind the read We run a dedicated Prostate Program and specialize in reading prostate MRI exams. DeepHealth’s CE-marked Prostate Suite, including Prostate AI, is also part of TRANSFORM, the UK’s largest prostate screening trial in a generation, which is expected to analyze more than 100,000 scans over the course of the study.
Why MRI before a biopsy?
A standard biopsy samples the gland at 10 to 12 set points. MRI reads the whole gland first, so any biopsy that follows can be aimed at the areas that look suspicious.
93%
of clinically significant prostate cancers were found by MRI in the PROMIS study, against 48% by biopsy.
48%
were found by standard blind biopsy in the same study. Ahmed HU, et al. PROMIS. The Lancet, 2017.
Studies show prostate MRI has a negative predictive value of about 90%: when the MRI shows no suspicious area, roughly 9 in 10 men have no significant prostate cancer.
Multi-parametric technique
Our Prostate MRI Program reads four sequences rather than one — high-quality anatomic T2 imaging plus three functional sequences — an approach shown to raise both sensitivity and specificity for cancer detection.
T2-weighted
The anatomic backbone of the study: the detailed picture of the gland’s structure.
DWI
Diffusion-weighted imaging reads the restricted movement of water molecules seen with prostate cancer.
DCE
Dynamic contrast enhancement follows blood flow through the gland, acquired every three seconds and analyzed as time-function curves.
A prescription from your physician or urologist is required to schedule a diagnostic prostate MRI.
The PI-RADS v2.1 assessment framework
For men requiring full diagnostic staging or follow-up of abnormal lab work, RadNet offers prostate MRI only at facilities equipped with 3T MRI. Contracted radiologists, including prostate subspecialists, evaluate high-resolution T2-weighted, diffusion-weighted and dynamic contrast-enhanced sequences, assigning a standardized PI-RADS score.
- PI-RADS 1 · Very low likelihood Clinically significant cancer is highly unlikely to be present.
- PI-RADS 2 · Low likelihood Clinically significant cancer is unlikely to be present.
- PI-RADS 3 · Intermediate The presence of clinically significant cancer is equivocal.
- PI-RADS 4 · High likelihood Clinically significant cancer is likely to be present.
- PI-RADS 5 · Very high likelihood Clinically significant cancer is highly likely to be present.
Your doctor interprets the score with PSA density, history and other findings to decide next steps, which may include a targeted biopsy.
Beyond the scan
Targeted MRI-ultrasound fusion biopsy
- How it works High-resolution 3D lesion maps from a prior mpMRI are overlaid in real time onto transrectal or transperineal ultrasound images.
- Why it matters Guides the needle to suspicious areas seen on MRI, which finds more clinically significant cancers than standard biopsy; standard samples may also be taken.
Available in select markets.
TULSA-Pro ablation
- What it is An incision-free, zero-radiation procedure using directional ultrasound heat to ablate diseased prostate tissue under real-time MRI thermal monitoring. FDA-cleared and performed on an outpatient basis.
- Quality of life Your doctor can explain how its risk of urinary and sexual side effects compares with surgery or radiation.
Performed at dedicated TULSA centers in California and Arizona.
Molecular PSMA PET/CT staging
- Targeted radiotracer imaging Pylarify® binds directly to prostate-specific membrane antigen, a protein overexpressed in about 95% of prostate cancers.
- Indication Helps evaluate suspected spread in men with high-risk disease and suspected recurrence when PSA rises after treatment. How well it finds disease depends partly on the PSA level.
Available in select markets.
Prostate imaging questions
A 10–15 minute non-contrast screening MRI for men 45 and older who have not had a previous prostate biopsy or a prostate cancer diagnosis. It is non-invasive, with no endorectal probe, no IV contrast and zero radiation.
A PSA test is recommended but not required. Talk with your doctor about whether screening is right for you.
Begin a clear-liquid diet starting eight hours before your appointment — water, soup broth, Jello, hot or cold tea, Gatorade and water-based popsicles. Take two Gas-X 125mg soft gels 25 minutes before your scheduled appointment. For those with chronic constipation, an at-home enema is recommended before the exam; without it there is a 10–15% chance of limited image quality in the posterior area, where prostate cancer is most common, and this will be noted in the exam report.
Enhanced Prostate Screening is not yet covered by insurance; the exam is $275. Diagnostic prostate MRIs for symptomatic or previously diagnosed patients are billed directly to insurance.
In the PROMIS study (The Lancet, 2017), MRI found 93% of clinically significant prostate cancers, while a standard biopsy found 48%. An MRI-first pathway gives your urologist better information before any biopsy — and can spare many men an unnecessary one.
The screening exam is designed to be comfortable for those with claustrophobia — your head remains outside the scanner for the duration.
PI-RADS v2.1 is the standardized framework radiologists use to grade prostate MRI findings from 1 (very low risk) to 5 (very high risk), so your care team and urologist share one clear language for what was found and what to do next. Scores of 4 or 5 typically lead to a targeted biopsy recommendation.
For suspicious findings, targeted MRI-ultrasound fusion biopsy overlays your MRI lesion map in real time onto ultrasound images, guiding the needle to suspicious areas seen on MRI. This finds more clinically significant cancers than standard biopsy, and standard samples may also be taken.
Usually not. Prostate imaging deals with three problems centered on the gland: cancer, benign enlargement, and inflammation (prostatitis). Needing to go often, a weak stream or waking in the night are far more often caused by an enlarged or inflamed prostate than by cancer. Still, tell your doctor about any of these symptoms so the cause can be found and treated, if needed. Prostate MRI can often help tell those apart without any invasive probing, though it cannot always distinguish cancer from inflammation, and if treatment for an enlarged prostate is needed, the same scan measures the gland for your urologist to plan it.
EPS is offered in Arizona, California, Delaware, New York and Texas. Use the locator below to check availability near you.
Schedule prostate care
Enhanced Prostate Screening, diagnostic and staging prostate MRI, fusion biopsy and PSMA PET/CT.
